Candidas are usually commensal yeast of the digestive and urogenital mucosas. They become pathogenic only when favorable conditions arise in the host.
C. krusei is generally a commensal yeast of mucous membranes and teguments, but it is also found in nature. This yeast is seldom isolated from clinical samples such as hemocultures (2%). However, the mortality rate attributed to C. krusei is high (40%), with primary resistance to certain azoles being a problem (fluconazole, itraconazole…). The isolation and rapid identification of C. krusei is thus essential for determining the correct therapeutic option. Traditionally, biochemical tests are used in the identification of C. krusei. The disadvantage of the carbon auxanogram (study of the assimilation of monosaccharides as a source of carbon and energy) and the zymogram (study of the use of monosaccharides in anaerobiosis), is that there is a long 24 to 48 hour wait before the tests can be read.
ELITex krusei is a rapid identification test of C. krusei that uses latex particles sensitized with a specific C. krusei monoclonal antibody.